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Serveur d'exploration MERS

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Long-term Respiratory Complication in Patients with Middle East Respiratory Syndrome: 1-year Follow-up After the 2015 Outbreak in South Korea

Identifieur interne : 000D17 ( Main/Exploration ); précédent : 000D16; suivant : 000D18

Long-term Respiratory Complication in Patients with Middle East Respiratory Syndrome: 1-year Follow-up After the 2015 Outbreak in South Korea

Auteurs : Kang Il Jun ; Wan Beom Park ; Gayeon Kim ; Jae-Phil Choi ; Ji-Young Rhee ; Shinhye Cheon ; Jun-Sun Park ; Yeonjae Kim ; Joonsung Joh ; Bum Sik Chin ; Pyeong Gyun Choe ; Ji Whan Bang ; Sang-Won Park ; Nam Joong Kim ; Dong-Gyun Lim ; Yeon-Sook Kim ; Myoung-Don Oh ; Hyoung-Shik Shin

Source :

RBID : PMC:7107210

Abstract

AbstractBackground

There are few data about long-term respiratory complications following Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection. This study aimed to evaluate respiratory functions and radiologic sequelae according to the severity of infection one year after the patients experienced MERS-CoV infection.

Methods

A total of 73 patients undergoing MERS-CoV infection during the 2015 MERS outbreak in South Korea were enrolled in this prospective multicenter study. Pulmonary function tests and 6-minute walking tests were performed 1 year after infection. Radiologic sequelae was defined as fibrosis or atelectasis on chest computer tomography and severe pneumonia was defined as that requiring oxygen therapy. Multivariate linear regression tests were used to evaluate the effect of infection severity on respiratory function.

Results

At the time of MERS-CoV infection, 18 patients had no pneumonia, 35 experienced mild pneumonia, and 20 did severe pneumonia. The median age was not different between groups (P = 0.942). Forced vital capacity (FVC) was 102.6%, 94.9%, and 88.7% in the no, mild, and severe pneumonia group, respectively (P = 0.010) and forced expiratory volume in 1 second was 105.3%, 95.7%, and 91.7% (P = 0.057). Diffusing capacity (DLCO) was significantly lower in the severe pneumonia group than in the no or mild pneumonia group (78.3% vs. 89.4% or 88.6%, P = 0.035). In multivariate analyses, FVC and DLCO were significantly correlated with infection severity after adjustment with age, sex, underlying lung disease, and smoking. There was no difference in the walking distance of 6 minute tests between groups. Radiologic sequelae were shown in 18.8%, 65.6%, and 100% in the no, mild, and severe pneumonia group, respectively (P < 0.001).

Conclusion

The patients with more severe pneumonia by MERS-CoV had more impaired respiratory function in one year follow-up, which was compatible with radiologic sequelae.

Disclosures

All authors: No reported disclosures.


Url:
DOI: 10.1093/ofid/ofx163.1508
PubMed: NONE
PubMed Central: 7107210


Affiliations:

Links toward previous steps (curation, corpus...)

Le document en format XML

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<name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name>
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<name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
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<country>Korea, Republic of (South)</country>
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<name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name>
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<name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name>
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,
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,
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</nlm:aff>
<wicri:regionArea># see nlm:aff region in country</wicri:regionArea>
</affiliation>
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<author>
<name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name>
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<addr-line>Seoul</addr-line>
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<country>Korea, Republic of (South)</country>
</nlm:aff>
<wicri:regionArea># see nlm:aff region in country</wicri:regionArea>
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<name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name>
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<nlm:aff id="AF0003">
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,
<addr-line>Seoul</addr-line>
,
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</nlm:aff>
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<title level="j">Open Forum Infectious Diseases</title>
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<div type="abstract" xml:lang="en">
<title>Abstract</title>
<sec id="s1">
<title>Background</title>
<p>There are few data about long-term respiratory complications following Middle East Respiratory Syndrome coronavirus (MERS-CoV) infection. This study aimed to evaluate respiratory functions and radiologic sequelae according to the severity of infection one year after the patients experienced MERS-CoV infection.</p>
</sec>
<sec id="s2">
<title>Methods</title>
<p>A total of 73 patients undergoing MERS-CoV infection during the 2015 MERS outbreak in South Korea were enrolled in this prospective multicenter study. Pulmonary function tests and 6-minute walking tests were performed 1 year after infection. Radiologic sequelae was defined as fibrosis or atelectasis on chest computer tomography and severe pneumonia was defined as that requiring oxygen therapy. Multivariate linear regression tests were used to evaluate the effect of infection severity on respiratory function.</p>
</sec>
<sec id="s3">
<title>Results</title>
<p>At the time of MERS-CoV infection, 18 patients had no pneumonia, 35 experienced mild pneumonia, and 20 did severe pneumonia. The median age was not different between groups (P = 0.942). Forced vital capacity (FVC) was 102.6%, 94.9%, and 88.7% in the no, mild, and severe pneumonia group, respectively (P = 0.010) and forced expiratory volume in 1 second was 105.3%, 95.7%, and 91.7% (P = 0.057). Diffusing capacity (DLCO) was significantly lower in the severe pneumonia group than in the no or mild pneumonia group (78.3% vs. 89.4% or 88.6%, P = 0.035). In multivariate analyses, FVC and DLCO were significantly correlated with infection severity after adjustment with age, sex, underlying lung disease, and smoking. There was no difference in the walking distance of 6 minute tests between groups. Radiologic sequelae were shown in 18.8%, 65.6%, and 100% in the no, mild, and severe pneumonia group, respectively (P < 0.001).</p>
</sec>
<sec id="s4">
<title>Conclusion</title>
<p>The patients with more severe pneumonia by MERS-CoV had more impaired respiratory function in one year follow-up, which was compatible with radiologic sequelae.</p>
</sec>
<sec id="s5">
<title>Disclosures</title>
<p>
<bold>All authors:</bold>
No reported disclosures.</p>
</sec>
</div>
</front>
</TEI>
<affiliations>
<list></list>
<tree>
<noCountry>
<name sortKey="Bang, Ji Whan" sort="Bang, Ji Whan" uniqKey="Bang J" first="Ji Whan" last="Bang">Ji Whan Bang</name>
<name sortKey="Cheon, Shinhye" sort="Cheon, Shinhye" uniqKey="Cheon S" first="Shinhye" last="Cheon">Shinhye Cheon</name>
<name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name>
<name sortKey="Choe, Pyeong Gyun" sort="Choe, Pyeong Gyun" uniqKey="Choe P" first="Pyeong Gyun" last="Choe">Pyeong Gyun Choe</name>
<name sortKey="Choi, Jae Phil" sort="Choi, Jae Phil" uniqKey="Choi J" first="Jae-Phil" last="Choi">Jae-Phil Choi</name>
<name sortKey="Il Jun, Kang" sort="Il Jun, Kang" uniqKey="Il Jun K" first="Kang" last="Il Jun">Kang Il Jun</name>
<name sortKey="Joh, Joonsung" sort="Joh, Joonsung" uniqKey="Joh J" first="Joonsung" last="Joh">Joonsung Joh</name>
<name sortKey="Kim, Gayeon" sort="Kim, Gayeon" uniqKey="Kim G" first="Gayeon" last="Kim">Gayeon Kim</name>
<name sortKey="Kim, Nam Joong" sort="Kim, Nam Joong" uniqKey="Kim N" first="Nam Joong" last="Kim">Nam Joong Kim</name>
<name sortKey="Kim, Yeon Sook" sort="Kim, Yeon Sook" uniqKey="Kim Y" first="Yeon-Sook" last="Kim">Yeon-Sook Kim</name>
<name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name>
<name sortKey="Lim, Dong Gyun" sort="Lim, Dong Gyun" uniqKey="Lim D" first="Dong-Gyun" last="Lim">Dong-Gyun Lim</name>
<name sortKey="Oh, Myoung Don" sort="Oh, Myoung Don" uniqKey="Oh M" first="Myoung-Don" last="Oh">Myoung-Don Oh</name>
<name sortKey="Park, Jun Sun" sort="Park, Jun Sun" uniqKey="Park J" first="Jun-Sun" last="Park">Jun-Sun Park</name>
<name sortKey="Park, Sang Won" sort="Park, Sang Won" uniqKey="Park S" first="Sang-Won" last="Park">Sang-Won Park</name>
<name sortKey="Park, Wan Beom" sort="Park, Wan Beom" uniqKey="Park W" first="Wan Beom" last="Park">Wan Beom Park</name>
<name sortKey="Rhee, Ji Young" sort="Rhee, Ji Young" uniqKey="Rhee J" first="Ji-Young" last="Rhee">Ji-Young Rhee</name>
<name sortKey="Shin, Hyoung Shik" sort="Shin, Hyoung Shik" uniqKey="Shin H" first="Hyoung-Shik" last="Shin">Hyoung-Shik Shin</name>
</noCountry>
</tree>
</affiliations>
</record>

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